3,905 research outputs found
Geometry of percolating monopole clusters
We perform detailed measurements of the geometrical characteristics of the
percolating cluster of the magnetic monopole currents in the confining phase of
the lattice SU(2) gluodynamics. The Maximal Abelian projection is used to
define the monopoles. The use of the geometrical language is motivated by
recent observations that the full non-Abelian action associated with the
monopoles corresponds to point-like particles on the currently available
lattices. Scaling behavior of various quantities is observed.Comment: 3 pages, 4 figures, Lattice2002(topology
Π‘ΠΈΠ½ΡΠ΅Π· ΡΠ° Π΄Π΅ΡΠΊΡ ΠΏΠ΅ΡΠ΅ΡΠ²ΠΎΡΠ΅Π½Π½Ρ 5-ΡΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΡΠ»ΡΡΠ»ΡΡΠΎΠ½ΡΠ»Ρ Π»ΠΎΡΠΈΠ΄ΡΠ²
The effect of the structure of 5-(benzylthio)isoxazoles on selectivity of the synthesis of 5-(chlorosulfonyl)isoxazoles has been determined. The chemical behavior in relation to amines has been described.Aim. To develop the methods for the synthesis of 5-(chlorosulfonyl)- isoxazoles and 4-chloro-5-(chlorosulfonyl)isoxazoles as promising reagents for construction of prospective bioactive compounds.Results and discussion. The number of 5-(benzylthio)isoxazoles was obtained by cyclocondensation of N-hydroxyimidoyl chlorides or 2-chloro-2-(hydroxyimino) acetates with benzylethynylsulfide. Their oxidative chlorination with gaseous chlorine led to formation of the mixture of isoxazole-5-sulfonyl chlorides and 4-chloroisoxazole-5-sulfonyl chlorides. The ratio between these products in the mixture depended on the nature of the substitution group in position 3 of the isoxazole ring. For the synthesis of 4-chloro-5-(chlorosulfonyl)isoxazoles with acceptable yields the approach of an advance chlorination of 5-benzylthioisoxazoles by N-chlorosuccinimide with further oxidative chlorination was used.Experimental part. The synthesis of the starting and target compounds was performed in classic preparative conditions; flesh-chromatography; elemental analysis; LCMS; 1H and 13C NMR-spectroscopy were used.Conclusions. The reaction of oxidative chlorination of 5-(benzylthio)-3-isoxazoles has been studied. The synthetic approach for the previously unknown representatives of isoxazole-5-sulfonylchlorides has been developed.ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΡΡΡΡΠΊΡΡΡΡ 5-Π±Π΅Π½Π·ΠΈΠ»ΡΠΈΠΎΠΈΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΠΎΠ² Π½Π° ΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ 5-ΠΈΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΠΈΠ»ΡΡΠ»ΡΡΠΎΠ½ΠΈΠ»Ρ
Π»ΠΎΡΠΈΠ΄ΠΎΠ² ΠΈ Π²ΡΡΠ²Π»Π΅Π½ΠΎ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΡ
ΠΏΠΎ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΠΊ Π°ΠΌΠΈΠ½Π°ΠΌ.Π¦Π΅Π»ΡΒ ΡΠ°Π±ΠΎΡΡ β ΡΠΎΠ·Π΄Π°Π½ΠΈΠ΅ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΡΠΈΠ½ΡΠ΅Π·Π° 5-ΠΈΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΠΈΠ»- ΠΈ 4-Ρ
Π»ΠΎΡ-5-ΠΈΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΠΈΠ»ΡΡΠ»ΡΡΠΎΠ½ΠΈΠ»Ρ
Π»ΠΎΡΠΈΠ΄ΠΎΠ² ΠΊΠ°ΠΊ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
ΡΠ΅Π°Π³Π΅Π½ΡΠΎΠ² Π΄Π»Ρ ΠΊΠΎΠ½ΡΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎ Π±ΠΈΠΎΠ°ΠΊΡΠΈΠ²Π½ΡΡ
Π²Π΅ΡΠ΅ΡΡΠ².Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ ΠΈΡ
ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅. Π¦ΠΈΠΊΠ»ΠΎΠΊΠΎΠ½Π΄Π΅Π½ΡΠ°ΡΠΈΠ΅ΠΉ N-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈΠΈΠΌΠΈΠ΄ΠΎΠΈΠ»Ρ
Π»ΠΎΡΠΈΠ΄ΠΎΠ² ΠΈΠ»ΠΈ 2-Ρ
Π»ΠΎΡΠΎ-2-(Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈΠΈΠΌΠΈΠ½ΠΎ)Π°ΡΠ΅ΡΠ°ΡΠΎΠ² ΠΈΠ· Π±Π΅Π½Π·ΠΈΠ»ΡΠΈΠΎΠ°ΡΠ΅ΡΠΈΠ»Π΅Π½ΠΎΠΌ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½ΠΎ ΡΡΠ΄ 5-Π±Π΅Π½Π·ΠΈΠ»ΡΠΈΠΎΠΈΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΠΎΠ². ΠΡ
ΠΎΠΊΠΈΡΠ»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ Ρ
Π»ΠΎΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΡΠΌΠ΅ΡΠΈ 5-ΠΈΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΠΈΠ»ΡΡΠ»ΡΡΠΎΠ½ΠΈΠ»Ρ
Π»ΠΎΡΠΈΠ΄ΠΎΠ² ΠΈ 4-Ρ
Π»ΠΎΡ-5-ΠΈΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΠΈΠ»ΡΡΠ»ΡΡΠΎΠ½ΠΈΠ»Ρ
Π»ΠΎΡΠΈΠ΄ΠΎΠ², ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠ΅ ΠΌΠ΅ΠΆΠ΄Ρ ΠΊΠΎΡΠΎΡΡΠΌΠΈ Π·Π°Π²ΠΈΡΠΈΡ ΠΎΡ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ° Π·Π°ΠΌΠ΅ΡΡΠΈΡΠ΅Π»Π΅ΠΉ Π² ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠΈ 3 ΠΈΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ ΡΠΈΠΊΠ»Π°. ΠΠ»Ρ ΡΠΈΠ½ΡΠ΅Π·Π° 4-Ρ
Π»ΠΎΡ-5-ΠΈΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΠΈΠ»ΡΡΠ»ΡΡΠΎΠ½ΠΈΠ»Ρ
Π»ΠΎΡΠΈΠ΄ΠΎΠ² Ρ ΡΠ΄ΠΎΠ²Π»Π΅ΡΠ²ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΡΠΌΠΈ Π²ΡΡ
ΠΎΠ΄Π°ΠΌΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ Π²Π°ΡΠΈΠ°Π½Ρ ΠΏΡΠ΅Π΄Π²Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ Ρ
Π»ΠΎΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ΄ΡΠ° 5-Π±Π΅Π½Π·ΠΈΠ»ΡΠΈΠΎΠΈΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΠΎΠ² N-Ρ
Π»ΠΎΡΡΡΠΊΡΠΈΠ½ΠΈΠΌΠΈΠ΄ΠΎΠΌ Ρ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠΈΠΌ ΠΎΠΊΠΈΡΠ»ΠΈΡΠ΅Π»ΡΠ½ΡΠΌ Ρ
Π»ΠΎΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ.ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½Π°Ρ ΡΠ°ΡΡΡ. Π‘ΠΈΠ½ΡΠ΅Π· ΠΈΡΡ
ΠΎΠ΄Π½ΡΡ
ΠΈ ΡΠ΅Π»Π΅Π²ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ Π² ΠΊΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠ²Π½ΡΡ
ΡΡΠ»ΠΎΠ²ΠΈΡΡ
; ΠΌΠ΅ΡΠΎΠ΄Ρ ΡΠ»Π΅Ρ-Ρ
ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΠΈΠΈ, ΡΠ»Π΅ΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π°, Ρ
ΡΠΎΠΌΠ°ΡΠΎΠΌΠ°ΡΡ-ΡΠΏΠ΅ΠΊΡΡΠΎΠΌΠ΅ΡΡΠΈΠΈ, Π―ΠΠ 1Π ΠΈ 13Π‘-ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΊΠΎΠΏΠΈΠΈ. ΠΡΠ²ΠΎΠ΄Ρ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π° ΡΠ΅Π°ΠΊΡΠΈΡ ΠΎΠΊΠΈΡΠ»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ Ρ
Π»ΠΎΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ 5-Π±Π΅Π½Π·ΠΈΠ»ΡΠΈΠΎΠΈΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΠΎΠ² ΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½ ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ ΠΊ ΡΠ°Π½Π΅Π΅ Π½Π΅ΠΈΠ·Π²Π΅ΡΡΠ½ΡΠΌ ΠΏΡΠ΅Π΄ΡΡΠ°Π²ΠΈΡΠ΅Π»ΡΠΌ 5-ΠΈΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΠΈΠ»ΡΡΠ»ΡΡΠΎΠ½ΠΈΠ»Ρ
Π»ΠΎΡΠΈΠ΄ΠΎΠ².ΠΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ Π²ΠΏΠ»ΠΈΠ² ΡΡΡΡΠΊΡΡΡΠΈ 5-Π±Π΅Π½Π·ΠΈΠ»ΡΡΠΎΡΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΡΠ² Π½Π° ΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΡΡΡΡ ΡΡΠ²ΠΎΡΠ΅Π½Π½Ρ 5-ΡΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΡΠ»ΡΡΠ»ΡΡΠΎΠ½ΡΠ»Ρ
Π»ΠΎΡΠΈΠ΄ΡΠ² ΡΠ° Π·βΡΡΠΎΠ²Π°Π½Π° Ρ
ΡΠΌΡΡΠ½Π° ΠΏΠΎΠ²Π΅Π΄ΡΠ½ΠΊΠ° ΠΎΡΡΠ°Π½Π½ΡΡ
ΠΏΠΎ Π²ΡΠ΄Π½ΠΎΡΠ΅Π½Π½Ρ Π΄ΠΎ Π°ΠΌΡΠ½ΡΠ².ΠΠ΅ΡΠ° ΡΠΎΠ±ΠΎΡΠΈ β ΡΡΠ²ΠΎΡΠ΅Π½Π½Ρ ΠΌΠ΅ΡΠΎΠ΄ΡΠ² ΡΠΈΠ½ΡΠ΅Π·Ρ 5-ΡΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΡΠ»- ΡΠ° 4-Ρ
Π»ΠΎΡΠΎ-5-ΡΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΡΠ»ΡΡΠ»ΡΡΠΎΠ½ΡΠ»Ρ
Π»ΠΎΡΠΈΠ΄ΡΠ² ΡΠΊ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΈΡ
ΡΠ΅Π°Π³Π΅Π½ΡΡΠ² Π΄Π»Ρ ΠΊΠΎΠ½ΡΡΡΡΡΠ²Π°Π½Π½Ρ ΠΏΠΎΡΠ΅Π½ΡΡΠΉΠ½ΠΎ Π±ΡΠΎΠ°ΠΊΡΠΈΠ²Π½ΠΈΡ
ΡΠ΅ΡΠΎΠ²ΠΈΠ½.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΈ ΡΠ° ΡΡ
ΠΎΠ±Π³ΠΎΠ²ΠΎΡΠ΅Π½Π½Ρ. Π¦ΠΈΠΊΠ»ΠΎΠΊΠΎΠ½Π΄Π΅Π½ΡΠ°ΡΡΡΡ N-Π³ΡΠ΄ΡΠΎΠΊΡΡΡΠΌΡΠ΄ΠΎΡΠ»Ρ
Π»ΠΎΡΠΈΠ΄ΡΠ² Π°Π±ΠΎ 2-Ρ
Π»ΠΎΡΠΎ-2-(Π³ΡΠ΄ΡΠΎΠΊΡΡΡΠΌΡΠ½ΠΎ)Π°ΡΠ΅ΡΠ°ΡΡΠ² ΡΠ· Π±Π΅Π½Π·ΠΈΠ»ΡΡΠΎΠ°ΡΠ΅ΡΠΈΠ»Π΅Π½ΠΎΠΌ ΡΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½ΠΎ Π½ΠΈΠ·ΠΊΡ 5-Π±Π΅Π½Π·ΠΈΠ»ΡΡΠΎΡΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΡΠ². ΠΡ
ΠΎΠΊΠΈΡΠ½ΡΠ²Π°Π»ΡΠ½Π΅ Ρ
Π»ΠΎΡΡΠ²Π°Π½Π½Ρ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡΡ Π΄ΠΎ ΡΡΠ²ΠΎΡΠ΅Π½Π½Ρ ΡΡΠΌΡΡΡ 5-ΡΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΡΠ»ΡΡΠ»ΡΡΠΎΠ½ΡΠ»Ρ
Π»ΠΎΡΠΈΠ΄ΡΠ² ΡΠ° 4-Ρ
Π»ΠΎΡΠΎ-5-ΡΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΡΠ»ΡΡΠ»ΡΡΠΎΠ½ΡΠ»Ρ
Π»ΠΎΡΠΈΠ΄ΡΠ², ΡΠΏΡΠ²Π²ΡΠ΄Π½ΠΎΡΠ΅Π½Π½Ρ ΠΌΡΠΆ ΡΠΊΠΈΠΌΠΈ Π·Π°Π»Π΅ΠΆΠΈΡΡ Π²ΡΠ΄ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΡ Π·Π°ΠΌΡΡΠ½ΠΈΠΊΡΠ² Ρ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½Ρ 3 ΡΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ ΡΠΈΠΊΠ»Ρ. ΠΠ»Ρ ΡΠΈΠ½ΡΠ΅Π·Ρ 4-Ρ
Π»ΠΎΡΠΎ-5-ΡΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΡΠ»ΡΡΠ»ΡΡΠΎΠ½ΡΠ»Ρ
Π»ΠΎΡΠΈΠ΄ΡΠ² ΡΠ· Π·Π°Π΄ΠΎΠ²ΡΠ»ΡΠ½ΠΈΠΌΠΈ Π²ΠΈΡ
ΠΎΠ΄Π°ΠΌΠΈ Π²ΠΈΠΊΠΎΡΠΈΡΡΠ°Π½ΠΎ Π²Π°ΡΡΠ°Π½Ρ ΠΏΠΎΠΏΠ΅ΡΠ΅Π΄Π½ΡΠΎΠ³ΠΎ Ρ
Π»ΠΎΡΡΠ²Π°Π½Π½Ρ ΡΠ΄ΡΠ° 5-Π±Π΅Π½Π·ΠΈΠ»ΡΡΠΎΡΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΡΠ² N-Ρ
Π»ΠΎΡΠΎΡΡΠΊΡΠΈΠ½ΡΠΌΡΠ΄ΠΎΠΌ ΡΠ· ΠΏΠΎΠ΄Π°Π»ΡΡΠΈΠΌ ΠΎΠΊΠΈΡΠ½ΡΠ²Π°Π»ΡΠ½ΠΈΠΌ Ρ
Π»ΠΎΡΡΠ²Π°Π½Π½ΡΠΌ.ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½Π° ΡΠ°ΡΡΠΈΠ½Π°. Π‘ΠΈΠ½ΡΠ΅Π· Π²ΠΈΡ
ΡΠ΄Π½ΠΈΡ
ΡΠ° ΡΡΠ»ΡΠΎΠ²ΠΈΡ
ΡΠΏΠΎΠ»ΡΠΊ Ρ ΠΊΠ»Π°ΡΠΈΡΠ½ΠΈΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠ²Π½ΠΈΡ
ΡΠΌΠΎΠ²Π°Ρ
; ΠΌΠ΅ΡΠΎΠ΄ΠΈ ΡΠ»Π΅Ρ-Ρ
ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΡΡ, Π΅Π»Π΅ΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΡΠ·Ρ, Ρ
ΡΠΎΠΌΠ°ΡΠΎΠΌΠ°Ρ-ΡΠΏΠ΅ΠΊΡΡΠΎΠΌΠ΅ΡΡΡΡ, Π―ΠΠ 1Π ΡΠ° 13Π‘-ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΊΠΎΠΏΡΡ.ΠΠΈΡΠ½ΠΎΠ²ΠΊΠΈ. ΠΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π° ΡΠ΅Π°ΠΊΡΡΡ ΠΎΠΊΠΈΡΠ½ΡΠ²Π°Π»ΡΠ½ΠΎΠ³ΠΎ Ρ
Π»ΠΎΡΡΠ²Π°Π½Π½Ρ 5-Π±Π΅Π½Π·ΠΈΠ»ΡΡΠΎΡΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΡΠ² ΡΠ° ΡΠΎΠ·ΡΠΎΠ±Π»Π΅Π½ΠΎ ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ½ΠΈΠΉ ΠΏΡΠ΄Ρ
ΡΠ΄ Π΄ΠΎ ΡΠ°Π½ΡΡΠ΅ Π½Π΅Π²ΡΠ΄ΠΎΠΌΠΈΡ
ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π½ΠΈΠΊΡΠ² 5-ΡΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΡΠ»ΡΡΠ»ΡΡΠΎΠ½ΡΠ»Ρ
Π»ΠΎΡΠΈΠ΄ΡΠ²
SU(2) Gluodynamics and HP1 sigma-model embedding: Scaling, Topology and Confinement
We investigate recently proposed HP1 sigma-model embedding method aimed to
study the topology of SU(2) gauge fields. The HP1 based topological charge is
shown to be fairly compatible with various known definitions. We study the
corresponding topological susceptibility and estimate its value in the
continuum limit. The geometrical clarity of HP1 approach allows to investigate
non-perturbative aspects of SU(2) gauge theory on qualitatively new level. In
particular, we obtain numerically precise estimation of gluon condensate and
its leading quadratic correction. Furthermore, we present clear evidences that
the string tension is to be associated with global (percolating) regions of
sign-coherent topological charge. As a byproduct of our analysis we estimate
the continuum value of quenched chiral condensate and the dimensionality of
regions, which localize the lowest eigenmodes of overlap Dirac operator.Comment: 22 pages, 18 ps figures, revtex4. Replaced to match published version
(PRD, to appear
The fat oxidation rate at rest and under exercise load Β«until exhaustionΒ» in Nordic skiers
Objective: to study the fat oxidation rate during physical exercises of different intensity and to identify factors influencing this process in athletes. Materials and methods: highly qualified Nordic skiers (26 men, 11 women) were examined. Fat oxidation (FO) was determined by the indirect colorimetric technique within stepwise increasing cycle load in the test Β«to failureΒ». Results: FO for highly skilled skiers (MS and MSIL) was 0.17 g/min at rest and 0.77 g/min at the peak of the load, corresponding to the range of 40-60% of the maximal oxygen consumption (MOC). The level of skill was associated with a higher peak FO and its longer retention up to a load of 80-90% of the MOC. Age differences appeared only at the peak of the load, in the range of 60-70% of the MOC. There was a higher base and maximum FO in men, unlike women. Conclusions: the fat oxidation rate during exercise should be used in assessing the functional state of athletes when planning load regimes and preventing overtraining
Breed-Specific Hematological Phenotypes in the Dog: A Natural Resource for the Genetic Dissection of Hematological Parameters in a Mammalian Species
Remarkably little has been published on hematological phenotypes of the domestic dog, the most polymorphic species on the planet. Information on the signalment and complete blood cell count of all dogs with normal red and white blood cell parameters judged by existing reference intervals was extracted from a veterinary database. Normal hematological profiles were available for 6046 dogs, 5447 of which also had machine platelet concentrations within the reference interval. Seventy-five pure breeds plus a mixed breed control group were represented by 10 or more dogs. All measured parameters except mean corpuscular hemoglobin concentration (MCHC) varied with age. Concentrations of white blood cells (WBCs), neutrophils, monocytes, lymphocytes, eosinophils and platelets, but not red blood cell parameters, all varied with sex. Neutering status had an impact on hemoglobin concentration, mean corpuscular hemoglobin (MCH), MCHC, and concentrations of WBCs, neutrophils, monocytes, lymphocytes and platelets. Principal component analysis of hematological data revealed 37 pure breeds with distinctive phenotypes. Furthermore, all hematological parameters except MCHC showed significant differences between specific individual breeds and the mixed breed group. Twenty-nine breeds had distinctive phenotypes when assessed in this way, of which 19 had already been identified by principal component analysis. Tentative breed-specific reference intervals were generated for breeds with a distinctive phenotype identified by comparative analysis. This study represents the first large-scale analysis of hematological phenotypes in the dog and underlines the important potential of this species in the elucidation of genetic determinants of hematological traits, triangulating phenotype, breed and genetic predisposition
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